FORMER world No.1 Maria Sharapova's return to grand slam action after a 15-month doping suspension has ended at the hands of 16th seed Anastasija Sevastova.

The Latvian moved into the quarter-finals with a 5-7 6-4 6-2 win over the 30-year-old Russian star, whose five Grand Slam titles include the 2006 US Open.

Sharapova, who returned to the tour in April after her ban ended, had defeated world No.2 Simona Halep in the first round.

But despite pocketing the first set, her challenge fizzled out when she needed a medical timeout to treat a blister on her right hand.

She finished with 42 winners but 51 unforced errors against Sevastova, who also made the quarter-finals in 2016.

"Playing on Ashe stadium is an amazing atmosphere, every time. It's fun to play here," said 27-year-old Sevastova, who took victory on a fourth match point when Sharapova pushed a service return wide.

"The first set was very close. It could have gone either way. She played unbelievable throughout the first and second set and I just kept fighting, running for every ball.

"The emotions were high when I was 5-2 up in the final set. I wanted to close it so much."

Sevastova will play American Sloane Stephens in the last eight on Tuesday.